The Science of POM Wonderful

For centuries, the pomegranate has been valued as a symbol of health and has been the centerpiece of many traditional folk medicine practices. Learn more about the History & Culture of the pomegranate. In 1998, POM initiated modern scientific research to understand the health benefits of Wonderful variety pomegranates. To date, we have provided over $35M in research support to top scientists, including a Nobel Laureate, at leading universities around the world.

Over 65 total studies, including 17 clinical studies, have been published in peer-reviewed journals. Preliminary results have been encouraging and many additional research studies are in progress.

Selected publications on antioxidant composition, bioavailability, and safety

Antioxidant Composition

Comparison of Antioxidant Potency of Commonly Consumed Polyphenol-Rich Beverages in the United States
Navindra P. Seeram, Michael Aviram, Yanjun Zhang, Susanne M. Henning, Lydia Feng, Mark Dreher, and David Heber
Journal of Agricultural and Food Chemistry, published online January 26, 2008

Antioxidant Activity of Pomegranate Juice and Its Relationship with Phenolic Composition and Processing
Gil, MI, Tomas-Barberan, FA, Hess-Pierce, B, Holcroft, DM, and Kader, AA
Journal of Agricultural and Food Chemistry 2000, 48: 4581-4589

Bioavailability

Pomegranate Juice and Extracts Provide Similar Levels of Plasma and Urinary Ellagitannin Metabolites in Human Subjects
Seeram, N, Zhang, Y, McKeever, R, Henning, S, Lee, R, Suchard, M, Li, Z, Chen, S, Thames, G, Zerlin, A, Nguyen, M, Wang, D, Dreher, M, Heber, D
Journal of Medicinal Food 2008, 11(2): 390-394

Pomegranate Juice Ellagitannin Metabolites Are Present in Human Plasma and Some Persist in Urine for Up to 48 Hours1,2
Seeram NP, Henning SM, Zhang Y, Suchard M, Li Z, Heber D.
Journal of Nutrition 2006, 136(10):2481-5

Bioavailability of Ellagic Acid in Human Plasma After Consumption of Ellagitannins From Pomegranate (Punica granatum L.) Juice
Seeram N., Lee R., and Heber D.
Clinica Chimica Acta 2004, 348: 63-68

Safety & Drug Interaction

Pomegranate Juice Does Not Impair Clearance of Oral or Intravenous Midazolam, a Probe for Cytochrome P450-3A Activity
Farkas D., Oleson L., Zhao Y., Harmatz J., Zinny M., Court M., Greenblatt D.
Journal of Clinical Pharmacology 2007, 47(3): 286-294